SARS vaccine linked to liver damage in ferret study

first_imgDec 6, 2004 (CIDRAP News) – Researchers in Canada who found hepatitis in ferrets after injecting the animals with an experimental vaccine for SARS (severe acute respiratory syndrome) are urging caution as other investigators develop and test SARS vaccines.As reported in the November issue of the Journal of Virology, the study involved a vaccine developed by senior author Jingxin Cao, PhD, of the Public Health Agency of Canada’s National Microbiological Laboratory in Winnipeg, Man. Cao had created a vaccine from recombinant modified vaccinia virus Ankara (rMVA) and the distinctive spike protein that marks the SARS coronavirus (SARS-CoV). The trial vaccine is called rMVA-S.The team chose ferrets for the study on the basis of their reported susceptibility to SARS infection, Cao told CIDRAP News.At the Canadian Science Centre for Human and Animal Health’s Biosafety Level 4 lab in Winnipeg, three ferrets were injected with the rMVA-S vaccine, three with parental MVA, and three with saline solution. They received booster immunizations 2 weeks later.Then the ferrets were exposed intranasally to the SARS virus, which infected more than 8,000 people and killed 774 between November 2002 and July 2003.On the plus side, immunization with rMVA-S induced a rapid immune response following exposure to the virus, the researchers wrote. The ferrets displayed no clinical signs of illness, but viral RNA was found in pharyngeal swabs and blood samples taken from all the ferrets.But researchers unexpectedly discovered a downside when they checked the ferrets’ liver health. Ferrets vaccinated with rMVA-S and exposed to SARS-CoV had elevated levels of an enzyme that indicates liver damage. Examination of liver sections showed that the ferrets had severe hepatitis. Only mild hepatitis was found in the ferrets injected with parental MVA or saline.It’s uncommon to perform the tests that revealed the hepatitis, said Kelly Keith, acting communications manager for the Canadian Science Centre for Human and Animal Health. This study will help ensure that any other SARS vaccine will be safer, as scientists should know to check for this possible side effect.”Extra caution should be taken in proposed human trials of SARS vaccines due to the potential liver damage from immunization and virus infection,” the research report states.Cao said he hopes that others recognize the significance of the hepatitis among the vaccinated ferrets. “For future human vaccine development, we must pay attention to that effect,” he said.The lead author of the study, Hana Weingartl, PhD, head of special pathogens for Canada’s National Microbiology Laboratory in Winnipeg, said she and her fellow researchers are seeking a grant to continue their work. “We would like to look more closely at why we saw the liver damage in those animals,” she said. “It would be good to know what not to do.”The findings underscore how little is understood about SARS, which emerged in southern China in November 2002. Since its discovery, scientists have raced to contain it and develop a vaccine. Weingartl and Cao’s study is one of several vaccine investigations in various stages in several countries.Researchers need a better understanding of how the virus damages the host, Weingartl said.In an unrelated SARS vaccine investigation, the Chinese government yesterday announced that a vaccine proved safe and effective in a phase 1 clinical trial. Thirty-six volunteers who had been vaccinated reported no unusual physical reactions after 56 days, Agence France-Presse reported (AFP). In addition, antibodies were found in 24 of those vaccinated, the story said.Testing began in May with 18 men and 18 women from 21 to 40 years old following what the government termed successful animal tests, AFP reported. The vaccine won’t be ready for commercial use until two more testing phases are completed.Weingartl H, Czub M, Czub S, et al. Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets. J Virology 2004;78(22):12672-6 [Abstract]last_img read more

Aston Villa v Chelsea player ratings

first_imgSee also:Two off as Chelsea suffer defeat at VillaAngry Mourinho accuses Villa forwardMourinho keen to avoid referee FoyFollow West London Sport on TwitterFind us on Facebooklast_img

Chelsea v Dynamo Kiev: Blues duo return and Hazard is a sub

first_imgMidfield duo Nemanja Matic and Cesc Fabregas return to the Chelsea starting line-up for the Champions League clash with Dynamo Kiev at Stamford Bridge, while Eden Hazard drops back to the substitutes’ bench along with Gary Cahill.Cesar Azpilicueta starts for the Blues at right-back, with Baba Rahman coming in at left-back and Kurt Zouma partnering skipper John Terry at the heart of the defence.Chelsea: Begovic; Azpilicueta, Zouma, Terry, Baba; Ramires, Matic; Willian, Fabregas, Oscar; Diego Costa.Subs: Blackman, Cahill, Loftus-Cheek, Kenedy, Hazard, Pedro, Remy.Follow West London Sport on TwitterFind us on Facebooklast_img

Ohio’s Crop Progress — August 8th, 2016

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Predominately hot and dry weather continued this past week, causing crop and livestock conditions to deteriorate across the State, according to Cheryl Turner, Ohio State Statistician of the USDA’s National Agricultural Statistics Service.There were 6.6 days available for fieldwork for the week ending August 7th. Aside from sporadic shower activity on Friday, very few areas of the State received any rain during the week. Meanwhile, temperatures statewide remained about five degrees above normal for this time of the year. According to the U.S. Drought Monitor, nearly 43 percent of the State was rated as in “moderate drought” while another 27 percent was rated “abnormally dry”. Soybeans were progressing, but showing stress due to lack of rain; there were reports of soybeans looking burned in southern counties. In northern counties, growers reported corn stalks starting to fire at the bottom and leaves curling, while hay fields were browning. Oat harvest was nearly complete across the State. Hay second cutting was nearly finished while third cutting was progressing.Click here for the full reportlast_img read more

An Apps Driven Government? White House CIO Vivek Kundra and His Beliefs About the Cloud

first_imgalex williams Will Kundra succeed? We think so. But it will be another issue all together to gain adoption. The US. Congress is made up people who represent hundreds of constituencies. How they react to data centers shutting down will have its own affects on policy, no matter how great the benefits may be from cloud computing. TransparencyTransparency. We hear that term a lot but we’d argue that it’s a key reason why the American people have a more clear idea about the Obama Adminstration’s technology policy than prior administrations. It’s working for Obama and Kundera will continue to drive this topic. It’s illustrative of a core foundation of society in the belief that information about our government should flow freely. It also again demonstrates the power of the cloud. Takeaway: USA.gov and usaspending.gov are hallmarks of the Obama administration’s transparency. These services will continue to serve as examples for Kundra to show what can be achieved with cloud computing while continuing to embrace ideals centering around accountability. Tags:#cloud#cloud computing A Web Developer’s New Best Friend is the AI Wai… U.S. Government as a Platform: Apps Drive Public PolicyKundra maintains that the U.S. Government needs to operate as if it is a platform. The data generated from the platform must drive public policy. The federal government can not be an island separate from the people of the United States. Cloud computing will enable people to interact with the federal government, using the data to generate ideas and shift the debate about public policy issues.Takeaway: Cloud-based Data.gov is an example of the platforms that need to be built in order for the interaction to occur between citizens and the government. Related Posts center_img Top Reasons to Go With Managed WordPress Hosting An Infrastructure Shift Is UnderwayKundra talks a lot about the fundamental shift in infrastructure. He makes a connection between small business and the public sector. Small business is shedding its IT assets so they can save money but also work in real-time. it allows for productivity. The public sector can achieve the same results through consolidationTakeaway: It’s a matter of economics. Data centers consolidation and greater use of cloud-based applications can save billions. Upsides include cross-agency collaboration, greater degrees of interaction with citizens and a modern infrastructure for the workings of government. Why Tech Companies Need Simpler Terms of Servic… Vivek Kundra is Obama’s evangelist for cloud computing.On Friday, Kundra, the White House Federal CIO, faced one of his first big tests as he testified before the U.S. Congress about cloud computing and why the Obama administration believes it’s key in helping the government modernize its technology infrastructure.To get a picture of what Kundra believes, Cloudbook featured several videos featuring the president’s technology advisor. In reviewing the videos, Kundra repeats four key points about why it is critical for the U.S. Government to adopt cloud computing:Government IT is outdated and sometimes antiquated. People work on mainframes at work and on any number of Web oriented platforms at home. Federal data centers now number more than 1,000. Consolidations is essential but so are smarter methods for using apps that leverage the cloud.. The private market is cutting back in data centers through private clouds, hybrids and public services. Cloud-based, data driven services can drive policy. What this requires are platforms that provide a base for interaction between constituents and stakeholders in federal agencies. Interoperability between agencies across platforms requires cloud-driven services with core sets of standards. In such an environment, apps provide a level of portability and means for decreasing the need for multiple on-premise servers to run one application.Transparency for Kundra means the capability to get real-tine access to public data. The cloud makes that more of a reality.On to the videos…Government Is Far Behind the Private SectorIn his address last month to the Cloud Computing Forum and Workshop, Kundra lead his discussion by underscoring the problems he faced on his first day of work at the White House. It was like walking into a technology environment that was 10 years old. Obama had to fight to get a Blackberry. He used the story to illustrate how behind government is compared to the private sector.Takeaway: Kundra argues for modernization, making it clear that the government needs to be on par with the private sector. 8 Best WordPress Hosting Solutions on the Marketlast_img read more

Control What Is In Your Control – Episode 205

first_imgIf much in your business is outside of your control, you need to be wicked gooad at what is in your control. You can communicate. You can hustle. And you can care!last_img

Kashmiri students attacked at varsity

first_imgA group of students allegedly thrashed four fellow students from Jammu and Kashmir at a private university at Gangrar in Chittorgarh district of Rajasthan late on Friday, sparking off tension on the campus. One of the injured students, Tahir Majeed, was admitted to Sanwaliyaji Government Hospital in Chittorgarh.The clash occurred at Mewar University, when the two groups had an altercation over gate passes. The Kashmiri students alleged that the students from Bihar insulted them and attacked with knives and iron rods.Bilal Ahmad, Mohammed Ali and Ishfaq Ahmad Qureshi sustained minor injuries. The university’s dean and proctor rushed to the spot and brought the situation under control.The police have registered a First Information Report under Sections 323 (voluntarily causing hurt), 341 (wrongful restraint) and 34 (common intention) of the Indian Penal Code. Four accused were placed under preventive detention under Section 151 of the Criminal Procedure Code.Nasir Khuehami, spokesperson of the J&K Students’ Association, demanded immediate steps for the security of Kashmiri students at the university and medical care of the injured. “Such incidents will increase the sense of insecurity and anxiety among Kashmiri students and their parents and relatives,” he said.The university’s admission coordinator, Amit Kumar, told The Hindu that “nothing serious” had happened, and the issue was sorted out. Over 30 students from Jammu and Kashmir are enrolled at the university, and they had come under attack several times in the past. In 2017, some locals attacked Kashmiri students when they went to town to buy fruits and groceries. Four students were beaten up in 2016 over rumours of their cooking beef.last_img read more

MS Dhoni turns 36: When the cool cat lost his cool on the field

first_imgMahendra Singh Dhoni has achieved everything one can on a cricket field, and that too with the characteristic coolness that he has come to be associated with.Throwing the ball to a certain Joginder Sharma for the last over in the final of the World T20 in 2007 against Pakistan or promoting himself up the order ahead of Yuvraj Singh, the man-of-the-tournament, in the final of the 2011 World Cup, Dhoni’s risks have come to be part of a larger cricketing folklore.The ever-growing myth’s surrounding the man have filled the back pages throughout the nation over these many years, but then again some instances reminded us of his ‘humanness’.The times in which he seemingly “lost his cool” made the billions that call themselves fans, love and admire him more.Be it Dhoni’s on-field quips or “runs ins” with the opposition, what shines through is his earnest attempts to give his all for the country. ANGRY WITH BOWDEN!An instance when MS Dhoni lost his cool was in a game against Australia in 2012 when Kiwi umpire Billy Bowden had overturned the decision of the third umpire to declare Mike Hussey not-out.The Indian keeper had stumped the Aussie batsman off Suresh Raina’s bowling, but television replays suggested that Hussey got some part of his shoes behind the line when the bails were removed. When the decision was referred to the Third umpire, he had mistakenly flashed OUT on the screens in the stadium forcing the left-hander to take the long walk back.advertisementThe on-field umpires asked Hussey to continue his innings as a visibly displeased Dhoni was seen uncharacteristically arguing with Billy Bowden. MUST-YOU-FIZUR?Something that Mustafizur shall always remember after his debut in the first ODI against India in Mirpur back in June 2015, is that never mess with MS Dhoni.Bowling first, Mustafizur was involved in an incident with Rohit Sharma, as he constantly kept straying onto the India opener’s path in his follow-through. In the 25th over of the innings the Bangladeshi  speedster tried a similar tactic against the then Indian captain Dhoni, who wasn’t ready to have any of it.Dhoni wanted to take a single having tapped the ball towards mid-off, but Mustafizur, bowling from over the wicket decided to walk into Dhoni’s path after having a look at him over his shoulder. Dhoni continued his run and on his way nudged (read ‘shoved’) the debutant with his forearm who fell flat on the ground, and had to leave the field for a little while.   Dhoni was charged 75% of his match fee, and Mustafizur 50%.QUIRKY QUIPSMS Dhoni is synonymous with his never-ending commentary from behind the wickets, be it calling the ball-by-ball action or correctly pre-empting the opposition batsman’s next shot.While setting the field for Pragyan Ojha against New Zealand, S. Sreesanth was shifting away from his assigned fielding position he reminded, “Oye Sree! Udhar girlfriend nahi hain, idhar aa ja thoda” (Hey Sree, it’s not like your girlfriend is over there. Move over here).Or, when Ravindra Jadeja was quick to be reminded of Pujara’s purpose on the field as he kept missing his length. “Yeh ghoomega toh Pujara ko isiliye idhar rakha hai, woh udhar volleyball khelne ke liye nahi khada hai” (It will spin, that is why I have kept Pujara there to field, he is not there to play volleyball).Dhoni has also never shied away from giving back when other’s tried to put on over Captain Cool. He answered the way he knows best, with his signature quick wit.Earlier this IPL season, while Dhoni was playing for Rising Pune Supergiant, England legend Kevin Pietersen was on commentary duty and he decided to have some fun. KP was speaking to Manoj Tiwary, who was wired in and fielding at first slip next to Dhoni.Pietersen asked Tiwary to tell Dhoni that he was a better golfer than the former India skipper. Dhoni was prompt with his reply and Tiwary repeated that word for word on live air: “Tell him (KP), he is still my first Test wicket.” The whole commentary box burst out laughing while KP learnt a valuable lesson that day – never mess with MS Dhoni.last_img read more

Peter Coyote To Introduce Girl On The Edge At REEL Recovery Film

first_imgSan Rafael-based Alcohol Justice and Studio City-based Writers In Treatment have announced that actor Peter Coyote will introduce his new film Girl On the Edge to kick-off the 2nd Annual REEL Recovery Film Festival & Symposium – San Francisco Bay Area Edition.The four-day event will screen 18 select feature-length and short, fictional and factual alcohol and drug addiction-themed films in 14 sessions at two locations with a goal of engaging audiences with honest stories about the disease as well as the hope and opportunity for recovery. There will be expert panel discussions following most of the sessions.Girl on the Edge, follows the journey of a young girl struggling with the aftermath of a horrific trauma, the toll that it takes on her family and the last chance she has to overcome it in the most unlikely of places. A post-screening Q&A will take place with Producer/Director Jay Silverman, and actor Mackenzie Phillips. Immediately following there will be a VIP Reception at the Hotel Kabuki with live music by singer/songwriter Elizabeth Edwards.The festival ends on Sunday June 14, 2015 with a Robin Williams Tribute, featuring a screening of his 1998 movie Patch Adams. The film will be followed by Comedians Into Recovery, live standup performances by three of Williams’ fellow comedians, Johnny Steele, Mark Ludholm, and Barry Diamond, with Jan Wahl as MC.Tickets to these events and everything in-between are available exclusively through BrownPaperTickets.com. For more information about the festival, and to view a PSA featuring Michael Pritchard, go to: FilmFestSFBay.org “The ticket price for most of the sessions is just $10,” stated Michael Scippa, director of the event. “But if there are seats available we’ll allow anyone admittance regardless of their ability to pay.”Alcohol Justice and Writers In Treatment are producing the festival with generous support from the San Francisco Sheriff’s Department, Duffy’s Napa Valley Rehab, Center Point, Inc., West America Bank, Kaiser Permanente Community Benefits Programs – Marin/Sonoma Area, Marin County Mental Health Substance Use Services, Ghilotti Construction Company, KRON-TV, the Michael Basso Foundation, Muir Wood Adolescent and Family Services, KPOO-FM, North Bay Recovery Center, Hotel Kabuki, Book Passage Book Store, and many Bay Area individuals and families.last_img read more

Man shot dead in Fox Hill overnight by Bahamas Police

first_imgFacebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsApp#Bahamas, November 24, 2017 – Nassau – Late today Police confirm that a man is dead after getting into a gun battle with Police.   The incident unraveled in Fox Hill last night around 10, at an apartment on Abner Street.  Intel led officers to the residence, and as police approached the yard, a man reportedly known to Police pulled a firearm from hidden in his clothing and pointed it at officers.In response and in fear for their lives explained the report, Police shot the suspect and recovered an illegal gun.  At the hospital, the suspect was pronounced dead.  There is now launched an investigation into the shooting.#MagneticMediaNews#manshotdeadinNassau Related Items:#magneticmedianews, #manshotdeadinNassaulast_img read more